urkish Association of Pharmaceutical and Medicinal Chemistry organized the 1st International Meeting on Medicinal and Pharmaceutical Chemistry (IMMPC-1) that was held in Ankara on September 25-28, 2002.

his first meeting focused on experimental and relevant computational approaches to the drug discovery as well as drug metabolism while emphasizing on antiviral, anticancer and COX-2 inhibitor drugs. Please see the scientific program and the list of posters of the meeting for details.

e hope that this meeting was a goog opportunity to the scientists from all over the world to meet in Turkey and share their experiences. You may see some pics from the meeting in the picture gallery.

herefore, on behalf of the Turkish Association of Pharmaceutical and Medicinal Chemistry, I sincerely thank to all invited speakers and attendees for being a part of this first exciting meeting.

We hope to see you in Turkey for the second of this meeting (IMMPC-2) that will be held in Antalya on October 2004.

With our kind regards,

Prof. Dr. M. Fethi Sahin
President

PICTURE GALLERY

Closing picture from the attendess of IMMPC-1


Prof. Dr. Eric De Clercq	Prof. Dr. Ulrike Holzgrabe


Assis. Prof. Dr. Roberta S. King Prof. Dr. M. Fethi Þahin Prof. Dr. Erdoðan Berçin	Prof. Dr. Nico Vermeulen Prof. Dr. Hakký Erdoðan Prof. Dr. Fethi ÞAhin


Dr. Joan Caturla	Dr. Osman Güner


Prof. Dr. Laurence H. Hurley Prof. Dr. M. Fethi ÞAhin Dr. Kudret Aytemir	Dr. Zhaoyin Wang


Prof. Dr. Henk Timmermann Prof. Dr. Eric De Clercq Prof. Dr. M. Fethi Þahin	Prof. Dr. Anna Tsantili-Kakoulidou


Prof. Dr. Joseph G. Cannon Prof. Dr. Michael W. Duffel Prof. Dr. David Nichols Assis. Prof. Dr. Roberta S. King Prof. Dr. Mustafa Ýlhan	Prof. Dr. Robert J. Linhardt Prof. Dr. David Nichols Prof. Dr. Shalom Sarel


Prof. Dr. Gilles Gosselin	Prof. Dr. Laurence H. Hurley Prof. Dr. M. Fethi ÞAhin

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SCIENTIFIC PROGRAMME

September 25, 2002 Wednesday
09.00-17.30	Registration
17.30-18.00	Opening Ceremony and President's speach
18.00-21.00	Welcome Cocktail
September 26, 2002 Thursday
Morning Session
08.00-09.30	Registration
09.30-10.15	Medicinal Chemistry: Where has it been? Where is it now? Where is it going? Joseph G. Cannon (University of Iowa, USA)
10.20-10.50	Coffee Break
10.50-11.25	Histamine receptors: a good place for medicinal chemists to meet Henk Timmermann (Vrije Universiteit, Holland)
11.30-12.05	The quest to understand the structure-activity relationships of serotonin 5-HT2A agonists David Nichols (Purdue University, USA)
12.15-13.30	Lunch Break
Afternoon Session
13.30-14.05	Approaches and pitfalls to anticancer drug design James P. Snyder (Emory University, USA)
14.10-14.45	The evolution of DNA as a receptor for cancer therapeutics Laurence H. Hurley (University of Arizona, USA)
14.50-15.25	Carbohydrate-based anti-cancer therapeutics Robert J. Linhardt (University of Iowa, USA)
15.30-16.00	Coffee Break
16.00-16.35	Prostate tumor inhibiting CYP17 inhibitors Rolf W. Hartmann (University of the Saarland, Germany)
16.35-17.10	Novel method for affinity proteins to Pt-damaged DNA by new beads Hiroaki (Yohmei) Okuno (National Institute of Bioscience and Human Tech. ,Japan)
September 27, 2002 Friday
Morning Session
09.30-10.15	Progress in anti-HIV drug design Eric De Clercq (Katholieke Universiteit, Belgium)
10.20-10.50	Coffee Break
10.50-11.25	Recent Advances in anti-hepatitis B virus agents David Chu (The University of Georgia, USA)
11.30-12.05	L-Enantiomers of Natural 2'-Deoxynucleosides Revisited: LdT and L-dC as Potent and Selective Anti-HBV drugs Gilles Gosselin (Universite Montpellier II, France)
12.15-13.15	Lunch Break
13.15-14.30	Poster Presentation
Afternoon Session
14.30-15.05	Catalytic specificity in sulfation: model studies on an aryl (phenol) sulfotransferase Michael W. Duffel (University of Iowa, USA)
15.10-15.45	Inhibition of sulfotransferases by NSAIDs Roberta S. King (University of Rhode Island, USA)
15.50-16.20	Coffee Break
16.20-16.55	Cytochromes P450: Prediction of Metabolism on the basis of molecular mechanisms and computations Nico Vermeulen (Vrije Universiteit, Holland)
17.00-17.35	An approach to the synthesis of artificial peptides and proteins Jean Martinez (Universites Montpellier I et II, France)
September 28, 2002 Saturday
Morning Session
09.30-10.15	The discovery of Vioxx, a cyclooxygenase-2 inhibitor Zhaoyin Wang (Merck Research Labs, USA)
10.20-10.50	Coffee Break
10.50-11.25	2-Phenyl-4-pyrones. A novel series of selective cyclooxygenase-2 inhibitors Joan Caturla (Almirall Prodesfarma, Spain)
11.30-12.05	Docking interactions of inhibitors with their receptors including those of potential selective inhibitors against cyclooxygenase-2 Eiichi Akaho (Kobe Gaukin University, Japan)
12.15-13.15	Lunch Break
13.15-14.30	Poster Prensentation
Afternoon Session
14.30-15.05	A pharmacophore strategy for developing novel ligands in drug discovery Osman Güner (Accelrys, USA)
15.10-15.45	The impact of physicochemical properties in early drug discovery Anna Tsantili-Kakoulidou (University of Athens, Greece)
15.50-16.05	Coffee Break
16.05-16.40	Allosteric modulation of receptors: a way to enhance the ligand binding to muscarinic acetylcholine receptors Ulrike Holzgrabe (Bayerische Julius-Maximilians Universitat, Germany)
17.00-17.35	Structure and activity studies of glycine receptor ligands Janina Karolak-Wojciechowska (Technical University of Lodz, Poland)
17.40	Closing Ceremony
20.30-24.00	Gala Dinner

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POSTER PRESENTATIONS

Name of Presenting Author	Poster Title
Abouzid, K. A. M.	Synthesis and anti-inflammatory activity of novel indazolones
Akoðlu, Ç.	Amide derivatives of [6-(3-methyl-5-phenyl-pirazol-1-yl)-3(2H)-pyridazinon-2-l]acetic acid as analgesic and antiinflammatory compounds
Alagarsamy, V.	Synthesis and antihistaminic activity of some novel 2,3-disubstituted quinazolones
Algül, Ö.	Preparation And Antibacterial Activity Of Chiral And Achiral Bridged- And Fused-Ring Heterocyclic Compounds Against Methicillin-Resistant Staphylococcus Aureus
Alper, S.	Synthesis and Antimicrobial Activity of Some New 1,4-Benzoxazine-3-on Derivatives
Altýntaþ, H.	Synthesis and Evaluation of Antimicrobial Activity of some 4-Carbethoxymethyl-2 -[(N,N-disubstituted thiocarbamoylthio)-acylamino]thiazoles
Arman, A.	Isolation of Single-Stranded derived DNA Aptamers for Growth Hormone Receptor
Atay, O.	Quantitative Determination of Propanolol HCl- Hydrochlorothiazide in Pharmaceuticals Using Spectroscopic and High Performance Liquid Chromatography Methods
Atay, O.	Determination of Active Ingredients In The Pharmaceutical Formulations Containing Metoprolol tartarat, Hydrochlorothiazide by Spectrophotometric and High Performance Liquid Chromatography Methods
Ayhan-Kýlcýgil, G.	Synthesis and antimicrobial investigations of some novel thiadiazolyl- and triazolylbenzimidazoles
Baran, A.	Preparation of new bromoconduritol and chloroconduritol isomers
Barkýn, B.	Determination of Enantioselectivity of Some Lipases Towards Ibuprofen and Ketoprofen Ethyl Esters by High-performance Liquid Chromatography
Bekçe, B.	Quantitative determination of rofecoxib in pharmaceutical preparations
Biçer, E.	Spectroscopic Characterization and Voltammetric Behaviour of VO₂(H₂O)(Q) (Q = 8-hydroxyquinolinate ion) Complex
Bora, Gh.	New Prodrugs From The Class Of Antiinflammatory Non-Steroidic Acids
Bora, Gh.	Spectroscpic Investigation Of The Metal-Ligand Coordination In Some Diclofenac Compexes
Bora, M.	X-Rax Spectroscopy Investigations Of Na-Diclofenac-Cyclodextrins Interactions
Bora, V.	Mass-Spectrometry And Uv Spectroscopy For The Class Of Some Antiinflammatory Nonsteroidic Acids
Bozdað-Dündar, O.	Studies on the synthesis of some novel oxime ether derivatives
Bozdað-Dündar, O.	Synthesis and Antimicrobial Activity of Flavone-3’-Carboxaldehyde Oxime Ether Derivatives
Bozdað-Dündar, O.	Synthesis and Antidiabetic Activity of Some New Furochromonyl-2,4-Thiazolidinediones
Bulut, I.	Synthesis, Spectroscopic, Thermal and Voltammetric Properties of Cobalt(II) Complex Containing Saccharin and Nicotinamide
Canpolat, E.	Antimicrobial Effects Of Mononuclear Complexes Of Two New vic-Dioxime Ligands
Ceylan, M.	Synthesis and antimicrobial activities of some new flavone derivatives
Coþkun, E.	Investigation of Electrochemical Behaviour of Ni(II)-Eriochrome Black T Complex
Çakýr, B.	Synthesis of 2-[(2-oxobenzothiazolin-3-yl)methyl]-5-aminoalkyl / aryl-1,3,4-thiadiazole
Çakýr, S.	Novel Imidazole Adduct of NH₄VO₃ in Solid State
Çalýþkan, B.	Investigation of the addition products of 2-mercaptonicotinic acid with b-nitrostyrene derivatives and their antimicrobial activities
Çapan, G.	Synthesis and antimicrobial evaluation of some novel 1,2,4-triazolylmercaptoacetylthiosemicarbazides and 1,2,4-triazolylmercaptomethyl thiadiazoles
Darmani, H.	The effect of an extract of Meswak (chewing stick) on fertility of male and female mice
Demirayak, Þ.	2-[2-(Thiazol-4-yl)phenoxy]acetophenone oxime and oxime ether derivatives and their antifungal activities
Doðruer, D. S.	A New Class of Antinociceptive Compounds; Alkanoic Acid Derivatives of 4,6-Diphenyl-3(2H)-pyridazinone
Dündar, Y.	Studies on the Synthesis and Antinociceptive Activity of 4-(2-oxo-2,3-dihydro-1,3-benzoxazol-3-yl)butanamide Derivatives
Dündar, Y.	(2-Oxobenzazolin-3-yl)alkanoic Acid Derivatives And Antinociceptive Activity
El-Kerdawy, M.	Activated Nitriles In Heterocyclic Synthesis: Part ll New Antibacterial And Antifungal Benzimidazoles
Gokce, I.	High Level Expression Of Fusion Proteins Using Third Domain Of Tola As Fusion Partner
Gokce, I.	Pore-Forming Toxins
Gökçe, M.	Synthesis and Antinociceptiv Activity of [(2-Oxobenzothiazolin-3-yl)methyl]-4-alkyl/aryl-1,2,4-triazolin-5-thiones
Gökçe, M.	Quantitative Determination of Aminosulprid by Infrared Spectrophotometry
Göksu, S.	A concise synthesis of 2-amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene
Göksu, S.	An easy synthesis of alnustone, a naturally occurring compound having biological activity
Görgülü, A. O.	Synthesis And Antimicrobial Activities Of The Metal Complexes A New Hetorocyclic Containing Xanthate Ligand
Gül, H. Ý.	Antiinflammatory activity of 3-benzoyl-1-methyl-4-phenyl-4-piperidinol hydrochloride
Gül, H. Ý.	Synthesis of some mono Mannich bases and corresponding azine derivatives and evaluation of their anticonvulsant activity
Gündoðdu-Karaburun, N.	Synthesis of some new thiazole derivatives and their antitumour activities
Gürsoy, A.	Synthesis and primary cyctotoxicity evaluation of 3-[[(3-phenyl-4(3H)-quinazolinone-2-yl)mercaptoacetyl]hydrazono]-1H-2-indolinones
Güzel, Ö.	Spectrophotometric determination of some drugs incorporating primary amino functions
Güzel, Ö.	Synthesis and antimicrobial evaluation of new 2-hydroxy-N-(3-oxo-1-thia-4-azaspiro[4.4]non-4-yl) /(3-oxo-1-thia-4-azaspiro[4.5]dec-4-yl)-2-phenylacetamide derivatives
Güzel, Y.	3D-QSAR Investigation of Nonsteroidal Estrogen Receptor Ligand Binding; Electron Topological (ET) Approach
Güzel, Y.	Using Electron Topological (ET) Method, Investigation of 3D-QSAR Model of Steroidal Estrogen Receptor Ligand Binding
Ýçbudak, H.	Thermal Analysis of Nicotinamide Complexes of Cobalt(II), Nickel(II) and Zinc(II) Chlorides
Javidnia, K.	A Sensitive HPLC Method for Study of Pharmacokinetic of Famotidine in Plasma
Karaburun, A. Ç.	Synthesis and antifungal activities of some aryl (3-methyl-benzofuran-2-yl) ketoximes
Karancý, Y.	Investigation of the addition products of L-cystein with dimethylbenzylidenemalonate derivatives and their antimicrobial activities
Kasýmoðullarý, Ö. B.	Synthesis and preliminary evaluation of imidazo[1,2-a]pyridine derivatives as possible antimycobacterials
Kaymakçýoðlu, K.	Metabolism of N-Phenyl-N'-(3,5-Dimethylpyrazole-4-yl)thiourea In Rats
Kýsmetli, E.	N,N-Diethyl-2,6,6-trimethyl-4-(3-nitrophenyl)-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxamide
Köksal, M.	Some New Mannich Bases of Benzoxazolinones With Analgesic and Antiinflammatory Activities
Küçükgüzel, Ý.	HPLC-UV Diode Array And LC-MS/MS Determination of in vivo Metabolites of 4-Nitro-2-Phenoxymethanesulfonanilide in Rats
Mazi, A.	Synthesis, Characterization And Antimicrobial Activities Of Diflunisal Hydrazide-Hydrazones
Mete, E.	An efficient synthesis of 4-amino-3-hydroxybutanoic acid (GABOB) via allyl cyanide
Miri , R.	Synthesis and Study of Cytotoxicity Activities of New Derivatives of Diindanopyridine on Cell Line
Moshafi, M. H.	Structure Activity Relationship Of N-substituted Piperazinyl Quinolones(Antibacterial Activities)
Nacak Baytaþ, S.	Studies on Novel 7-Acyl-5-chloro-2-benzoxazolinone Derivatives as Potent Analgesic and Antiinflammatory Agents
Najafi, R. B.	Design and Evaluation of Buccal Adhesive Prednisolone Tablets
Najafi, R. B.	In-Vitro Study Of Some Plant Essential Oils On Giardia Cyst Comparison With Metronidazol
Najafi, R. B.	Preparation of Mutant Strains of Tolypocladium inflatum (DSM915) by UV Radiation to Promote Production of CyclosporinA
Oruç, E.E.,	Synthesis And Evaluation Of Some Substituted 1,3,4-Thiadiazole Derivative
Ökcelik, B.	Two Novel 6-(5-Chloro-2-benzoxazolinone-7-yl)-4-phenyl-3(2H)-pyridazinone Derivatives as Potent Analgesic and Antiinflammatory Agents
Ökçelik, B.	Quantitative Determination of Disulfiram Containing Drugs by Infrared Spectrophotometry
Ölgen, S.	Anti-oxidant effects of new indole derivatives
Önkol, T.	Synthesis and antinociceptive activity (2-benzazolone-3-yl) propionamide derivatives
Özkanlý, F.	Antimicrobial Evaluation of Some 3-Oxo-5-benzylidene-6-methyl-(4H)-2-substitutedpyridazines
Özkýrýmlý, S.	Synthesis and antimicrobial activity evaluation of 3-(1,2,4-triazol-3-yl)-4-thiazolidinones
Parlakpýnar, H.	Physiological And Pharmacological Concentrations Of Melatonin Protect Against Doxorubucin-Induced Cardiotoxicity
Petkovska, R.	AAS Method for Determination of Selenium in Therapeutical Nutritions
Pierra, C.	Synthesis and comparative study of valinyl ester prodrugs of the L-enantiomer of deoxycytidine, a potent and selective anti-HBV agent
Sevin, F.	Studies on an Unexpected Products Via Singlet Oxygen Oxygenation of 5,6-Dihydro-1,4-oxathiins
Sývacý-Taþtaban, D. M.	Synthesis Of Some 2-[(Benzazole-2-Yl)Thio]-Diphenyl-Methylacetamide Derivatives And Their Antimicrobial Activity
Süzen, S.	Studies on the synthesis of some new benzopyran oxime ether derivatives
Tagiyev, D.B.,	Antimicrobial Activity Of Some Monoesters
Tosun, A. U.	Synthesis and anticonvulsant activities of (2/4-substituted) benzaldehyde-(5-chloro-2-oxobenzoxazoline-3-yl) acetohydrazone derivatives
Tozkoparan, B.	Protective effects of some thiazolo[3,2-b]-1,2,4-triazoles on ethanol-induced oxidative stress in liver and brain of mice
Ulusoy, N.	New 6-(4-Bromophenyl)-imidazo[2,1-b]thiazole Derivatives: Synthesis and Antimicrobial Activity
Ulusoy, N.	Synthesis and Antituberculosis Activity of Cycloalkylidenehydrazide and 4-Aza-1-thiaspiro[4.5]decan-3-one Derivatives of Imidazo[2,1-b]thiazole
Ur, F.	Synthesis of Some New 6-Methylimidazo[2,1-b]thiazole-5-carbo-hydrazide Derivatives and Their Antimicrobial Activities
Ünlu, S.	Synthesis and Antinociceptive Activity of 1-(3-methyl-2-benzoxazolinone-6-yl)-2-cyclicaminoethanones and ethanols
Ünsalan, S.	Determination of Isoniazid, Pyrazinamide and Rifampicin by HPLC
Ünsalan, S.	Synthesis and antitumor evaluation of certain triazene derivatives
Yerdelen, K. O.	Toxicity of some azines of acetophenone derived mono-Mannich bases by brine shrimp bioassay
Yýldýz-Ören, Ý.	DFT Calculation of Some Antimicrobial Active 1,4-Benzoxazine-3-one Derivatives
Yýlmaz, B.	Determinations of gemcitabine HCI and its metabolite (2-dFdU) in human plasma using by HPLC-DAD

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